4-{5-[bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid ethyl ester
[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester
CAS: 3543-74-6
Molecular Formula: C18H27N3O4
4-{5-[bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid ethyl ester - Names and Identifiers
4-{5-[bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid ethyl ester - Physico-chemical Properties
| Molecular Formula | C18H27N3O4 |
| Molar Mass | 349.42 |
| Density | 1.21±0.1 g/cm3(Predicted) |
| Melting Point | 98-101°C |
| Boling Point | 580.6±50.0 °C(Predicted) |
| Flash Point | 305°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.53E-14mmHg at 25°C |
| Appearance | Solid |
| Color | White to Brown |
| pKa | 14.26±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.572 |
4-{5-[bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid ethyl ester - Risk and Safety
| HS Code | 2933998350 |
4-{5-[bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid ethyl ester - Reference Information
| Introduction | 5-[bis (2-hydroxyethyl) amino]-1-methyl-1H-benzimidazole-2-butyrate Ethyl ethyl ester is also called 4-{5-bis-(2-hydroxyethyl) amino]-1-methyl-2-benzimidazole} methyl butyrate, which is an intermediate for the synthesis of bendamustine hydrochloride. Bendamustine hydrochloride (BendamustineHydrochloride) was first developed by Ozegowski and his colleagues in the Microbial Experimental Association in Jena, Germany in the early 1960s. The original purpose was to connect an alkylated nitrogen mustard to a purine and amino acid. |
| preparation | 5g(0.0202mol) of methyl 5-amino -1-methyl -1H-2-benzimidazole butyrate, 60ml of glacial acetic acid and 60ml of water were sequentially added to a 500ml three-mouth round bottom flask, cooled to 0 ℃, added 2.6ml(0.0521mol) of ethylene oxide, deicing bath, and naturally heated to room temperature for 10 hours. After the reaction is completed, add 50ml dichloromethane, slowly add 20g of sodium carbonate, stir for 1 hour, filter, and dry the filtrate with anhydrous sodium sulfate for 8 hours. Filtration, concentration under reduced pressure until no fraction is produced, 50ml of dichloromethane is added, stirred, filtered, and the solid is blasted and dried at 50 ℃ for 8 hours to obtain 5.8g of white-like solid, molar yield: 85.5%,HPLC:94.6%. |
Last Update：2024-04-09 21:54:55
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Product Name: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Request for quotationCAS: 3543-74-6
Tel: +86 021-37285211
Email: info@yudiaochem.com
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Product Name: Bendamustine Impurity 24 Visit Supplier Webpage Request for quotationCAS: 3543-74-6
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Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
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Multiple Specifications
Product Name: [1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester Bendamustine Related Visit Supplier Webpage Request for quotationCAS: 3543-74-6
Tel: 18301782025
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